What is Rh sensitization during pregnancy?
If you are Rh-negative, your red blood cells do not have a marker called Rh factor on them. Rh-positive blood does have this marker. If your blood mixes with Rh-positive blood, your immune system will react to the Rh factor by making antibodies to destroy it. This immune system response is called Rh sensitization.
What causes Rh sensitization during pregnancy?
Rh sensitization can occur during pregnancy if you are Rh-negative and pregnant with a developing baby (fetus) who has Rh-positive blood. In most cases, your blood will not mix with your baby’s blood until delivery. It takes a while to make antibodies that can affect the baby, so during your first pregnancy, the baby probably would not be affected.
But if you get pregnant again with an Rh-positive baby, the antibodies already in your blood could attack the baby’s red blood cells. This can cause the baby to have anemia, jaundice, or more serious problems. This is called Rh disease. The problems will tend to get worse with each Rh-positive pregnancy you have.
Rh sensitization is one reason it’s important to see your doctor in the first trimester of pregnancy. It doesn’t cause any warning symptoms, and a blood test is the only way to know you have it or are at risk for it.
- If you are at risk, Rh sensitization can almost always be prevented.
- If you are already sensitized, treatment can help protect your baby.
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